منابع مشابه
ACP Journal Club. Review: cholinesterase inhibitors do not reduce progression to dementia from mild cognitive impairment.
Review scope Included studies compared ChEIs (donepezil, rivastigmine, galantamine, or tacrine) with placebo for ≥ 1 month in adults with mild cognitive impairment (as defined by each study but including subjective memory complaint and relatively preserved daily functioning). Primary outcomes were progression to dementia, which included Alzheimer disease (National Institute of Neurological and ...
متن کاملACP Journal Club. An intensive lifestyle intervention increased remission from type 2 diabetes in overweight adults.
Patients: 5145 adults 45 to 76 years of age (mean age 59 y, 58% women, mean weight 101 kg) who had type 2 diabetes and a body mass index ≥ 25 kg/m2, or ≥ 27 kg/m2 if using insulin. Exclusion criteria included hemoglobin A1c level > 11%, blood pressure > 160 mm Hg systolic or > 100 mm Hg diastolic, plasma triglyceride level > 600 mg/dL, or inability to perform maximal graded exercise test or com...
متن کاملACP Journal Club. Cangrelor reduced ischemic PCI complications more than clopidogrel without increasing severe bleeding.
Commentary Clopidogrel, a prodrug with variable metabolism to the active form, has delayed onset of action often resulting in need for a glycoprotein IIb/IIIa–receptor inhibitor to ensure adequate platelet inhibition in patients having PCI, but at the expense of increased bleeding. Prasugrel and ticagrelor are new oral antiplatelet agents that overcome some clopidogrel disadvantages: Prasugrel ...
متن کاملACP Journal Club. Automated reminders and increasing intense support increased uptake of colorectal cancer screening.
Intervention: Automated intervention including automatically generated, EHR-linked reminders mailed to patients when screening was due (n = 1173); automated intervention plus assisted care with telephone support from medical assistants to complete screening (n = 1161); automated intervention and assisted care plus navigated interventions provided by a registered nurse (n = 1174); or usual care ...
متن کاملACP Journal Club. Adding aspirin to clopidogrel worsened outcomes in PCI patients receiving oral anticoagulants.
Commentary The optimal management of patients who need long-term oral anticoagulation and coronary stenting is unknown. Bleeding risks are substantial with triple oral anticoagulation therapy using an oral anticoagulant plus aspirin and clopidogrel for antiplatelet therapy. The WOEST trial showed a reduction in the primary endpoint of any bleeding in patients who received double therapy (oral a...
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 2008
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.97.1723